Refrigerants are fluids used by heating and cooling equipment (e.g., air conditioners, heat pumps, commercial chillers, and variable-refrigerant-flow (VRF) systems) to transfer heat. Some refrigerants present both a health and environmental hazard. Safety measures should be employed to reduce the potential for releases. A Refrigerant Safety Program can help prevent leaks or occupant exposure to refrigerants and halocarbons. Regular leak check and inspections safeguard occupants from potential risks.